Hydroxyapatite (HA, Ca10(OH)2(PO4)6) has chemical and crystallographic similarities to the mineral components of bone matrix and teeth. It is clinically used as bio-coatings for implants. Dental and orthopedics enable the adhesion and proliferation of osteoblast cells on the surface of the prosthesis, and as a result, it creates biological stabilization between the bone tissues and the implant. However, one of the main limitations when used for main bearing is its poor mechanical properties, such as low fracture toughness and tensile strength. To solve this problem, the special use of graphene or graphene oxide, which has a two-dimensional sheet structure consisting of hexagonal carbon atoms, with a large surface area, can be effective in improving strong mechanical properties and good biocompatibility. Therefore, in this work, HA nanocomposite has been made using collagen and graphene oxide.